NENUFAR: Study of Fast Ripples (also know as High Frequency Oscilliation) as a potential biomarker for epileptic zone

Nenufar and its predecessor Epifar, contributed to the development of an innovative medical device: a hybrid depth electrode that enables multi-scale investigation of human brain activity  This electrode combines macrocontacts and microscale tetrodes, allowing for the simultaneous recording of local field potentials (LFPs), multiunit activity, and single-neuron firing patterns (single unit activity). These electrodes are implanted in both cortical regions (such as the medial temporal lobe, insula, and cingulate cortex). This design enables the characterisation of both local microdynamics and long-range interactions, providing a unique window into brain function across spatial and temporal scales — from the activity of individual neurons to the emergence of large-scale oscillatory patterns.

This project is part of Benoit Marcy’s PhD thesis